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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: In this study, we identified the correlation between p53 functional activation and its genotype in fiveTo examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayFurther, the expression of p53 protein and four transcripts of well-known p53 target genes were investigatedThe results showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could beTo judge p53 function in a particular cell line, it is important to examine the p53 functional activation

Keywords： p53     esophageal squamous cell carcinoma     DNA damage    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved.Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53Among the 9 trialed patients with available TP53 sequencing results, the 6 patients with p53 mutationsIn a mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 1-15 doi: 10.1007/s11705-016-1562-6

Abstract: successfully demonstrated that these makaluvamines attack several key molecular targets, including the MDM2-p53

Keywords： synthesis     marine drugs     tricyclic pyrroloquinone alkaloid     cancer therapy     MDM2     p53    

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Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 41-44 doi: 10.1007/s11684-009-0009-6

Abstract: non-small cell lung cancer (NSCLC) and the relationship between Syk and clinicopathologic factors and p53Immunohistochemistry was applied to detect the expression of Syk and p53 protein in 39 cases of NSCLCThe Syk expression was positively correlated withthe p53 expression in NSCLC specimens ( = 0.025).

Keywords： Syk kinase     carcinoma     non-small-cell lung     tumor suppressor protein p53    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: The patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cisOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 229-237 doi: 10.1007/s11684-018-0616-1

Abstract: This retrospective analysis aimed to investigate the mutation profile of 16 common mutated genes inMutation profiling of 16 candidate genes were performed in bone marrow samples by using Sanger sequencingWe identified at least 1 mutation in 199 of the 259 samples (76.8%), and 2 or more mutations in 31.7%The results showed certain rules in the mutation profiling and concurrence of AML patients, which wasDefining the mutation spectrum and mutation pattern of AML will contribute to the comprehensive assessment

Keywords： leukemia     myeloid     acute     gene     mutation    

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P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

Frontiers in Energy 2023, Volume 17, Issue 2,   Pages 189-197 doi: 10.1007/s11708-023-0873-9

Abstract: Peer-to-peer (P2P) energy trading is an emerging energy supply paradigm where customers with distributedP2P energy trading can facilitate local power and energy balance, thus being a potential way to manageIt is of great importance to explore P2P energy trading via public power networks, to which most DERsIn this paper, the practical challenges of conducting P2P energy trading via public power networks areFinally, the way forward for facilitating P2P energy trading via public power networks is proposed.

Keywords： distribution network     local virtual private network     network charges     peer-to-peer (P2P) energy trading    

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Solomon P Wasser: medicinal use of mushroom (2019-9-19)

Solomon P Wasser(高级职称)

20 Jan 2021

Keywords： 农业科学    

An Interactive ServiceorientedP2P Networks Architecture Reference Model

Liu Ye,Liu Linfen,Zhuang Yanyan

Strategic Study of CAE 2007, Volume 9, Issue 9,   Pages 72-77

Abstract: <p style="text-align: justify;">An interactive service- oriented P2P networks architecture (ISPNA) is Based on the further analysis on the service demand of distributed P2P applications,  andconsidering the characteristics of P2P networks such as loose-coupled,  self-organizing,  andscalability,  the key availability enhancing issues of P2P networks are resolved by several differentp>

Keywords： P2P networks     architecture     reference model     resource     service    

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 123-138 doi: 10.1007/s11705-022-2194-7

Abstract: The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues.NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers.Because it is a quinone reductase, many bioimaging probes based on quinone structures target NAD(P)H:fluorescent, near-infrared and two-photon fluorescent probes, as well as nanosystems for delivering the NAD(P)valuable information for the future development of probes and nano-delivery systems that target NAD(P)

Keywords： NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Runt-related transcription factor 1 (RUNX1) is an essential regulator of normal hematopoiesis. Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemia (AML). However, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainly due to their elusive genetic characteristics. Here, based on 1741 patients with AML, we report a unique expression pattern associated with RUNX1 mutations in AML. This expression pattern was coordinated by target repression and promoter hypermethylation. We first reanalyzed a joint AML cohort that consisted of three public cohorts and found that RUNX1 mutations were mainly distributed in the Runt domain and almost mutually exclusive with NPM1 mutations. Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signature that significantly distinguished the patients with RUNX1 mutations from those with other AML subtypes. Furthermore, we explored the mechanisms underlying this signature from the transcriptional and epigenetic levels. Using chromatin immunoprecipitation sequencing data, we found that RUNX1 target genes tended to be repressed in patients with RUNX1 mutations. Through the integration of DNA methylation array data, we illustrated that hypermethylation on the promoter regions of RUNX1-regulated genes also contributed to dysregulation in RUNX1-mutated AML. This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying mechanisms in AML development.

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 5,   Pages 391-403 doi: 10.1631/FITEE.1400267

Abstract: The continuous emerging of peer-to-peer (P2P) applications enriches resource sharing by networks, butTherefore, P2P applications monitoring, in particular, P2P traffic classification, is becoming increasinglyIn this paper, we propose a novel approach for accurate P2P traffic classification at a fine-grainedsome special flows that are appearing frequently and steadily in the traffic generated by specific P2PExperimental results show that P2P applications can be classified with a true positive rate higher than

Keywords： Traffic classification     Peer-to-peer (P2P)     Fine-grained     Host-based    

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Solving Knapsack Problem by Hybrid Particle Swarm Optimization Algorithm

Gao Shang,Yang Jingyu

Strategic Study of CAE 2006, Volume 8, Issue 11,   Pages 94-98

Abstract: <p>The classical particle swarm optimization is a powerful method to find the minimum of a numericalEspecially the hybrid particle swarm optimization algorithm derived from across strategy A and mutationp>

Keywords： particle swarm algorithm     knapsack problem     genetic algorithm     mutation    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: Using exome sequencing, we identified a novel DNAH10 homozygous variant (c.589C > T, p.R197W)i> deficiency related to PCD in human and mouse models, which suggests that DNAH10 recessive mutation

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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Title Author Date Type Operation

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

Journal Article

Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Journal Article

construction integration technology in Brazil’s superlarge deep-water offshore oil and gas unit project (FPSO P67/P70)

Journal Article

P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

Journal Article

Solomon P Wasser: medicinal use of mushroom (2019-9-19)

Solomon P Wasser(高级职称)

20 Jan 2021

Conference Videos

An Interactive ServiceorientedP2P Networks Architecture Reference Model

Liu Ye,Liu Linfen,Zhuang Yanyan

Journal Article

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Journal Article

Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

Journal Article

Solving Knapsack Problem by Hybrid Particle Swarm Optimization Algorithm

Gao Shang,Yang Jingyu

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article